Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations.

This trend reached near significance ( P = 0.07, exact Wilcoxon test) in groups administered with CH505 sequential gp120 Envs when they were formulated in AS01E ( N = 8), with mean autologous tier 1 (CH505.w4.3)-neutralizing antibody ID50-titers of 2264 ± 2932, relative to those administered with CH505 TF Env gp120 alone formulated in AS01E ( N = 8), which by comparison, induced mean autologous tier 1 (CH505.w4.3)-neutralizing antibody ID50-titers of 630 ± 383.

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However, sequential gp120 Env-immunized macaques showed a trend of qualitatively better serum plasma-neutralizing antibody responses relative to those immunized repeatedly with TF Env gp120, both in terms of potency and breadth (Fig. 1a, b ).

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