Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility.

Gene set enrichment analyses (GSEA; Broad Institute 35 ) determined that nominally significant gene correlates of Cacna2d1 (Supplementary Data 1 ) were significantly enriched for plasma membrane localization (Fig. 2g ) and for functions related to neuronal function and excitability, including ion channel activity, substrate-specific channel activity, metal ion transmembrane transporter activity, ion transmembrane transporter activity, and receptor activity (Fig. 2h ).

also in 7,732 other papers