Interleukin 27 is increased in carotid atherosclerosis and promotes NLRP3 inflammasome activation.

PLoS One · 2017 · PMC5703457 · PMID 29176764

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did not reach statistical significanceno p-value reported

Increased expression of IL-27 and IL-27R in carotid atherosclerotic plaques qPCR analyses showed increased levels of IL-27p28 (p = 0.06), Ebi3 (p<0.001) and IL-27RA (p<0.001) mRNA in carotid plaques (n = 159) compared to control samples (n = 9), although the difference for IL-27p28 did not reach statistical significance ( Fig 1B–1D ).

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