Activation of the mitochondrial unfolded protein response promotes longevity and dopamine neuron survival in Parkinson's disease models.

5c,d ), pink-1 mutants exhibited a trend towards increased sensitivity to osmotic and heat stress that failed to reach significance (Fig. 5c,d ), and djr-1.1 exhibited a trend towards increased sensitivity to osmotic stress and significantly decreased survival under heat stress (Fig. 5c,d ). pdr-1 and pink-1 mutants exhibit activation of the mitochondrial unfolded protein response Since all three PD mutants showed increased sensitivity to stress, we next sought to determine whether these mutants exhibit activation of stress response pathways.

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In testing the PD mutants, we found that all three strains showed a trend towards decreased ethanol avoidance behavior, but the difference only reached significance in pdr-1 worms (Fig. 1g ).

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