TGF-β1/Smad3 Signaling Pathway Mediates T-2 Toxin-Induced Decrease of Type II Collagen in Cultured Rat Chondrocytes.

Toxins (Basel) · 2017 · PMC5705974 · PMID 29113082

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highly significantno p-value reported

p < 0.01 was considered as highly significant.

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showed a trendno p-value reported

The protein levels of MMP13, ALK5, Smad3, and P-Smad3 were significantly increased, the production of type II collagen was reduced in a dose-dependent manner in T-2 toxin-treated cells, TGF-β1 showed a trend level similar to its mRNA when compared with the control ( Figure 5 ). 2.4.

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