At day 10, the total number of hematopoietic cells within the BM of Jag2 fl/fl or Jag2 ECKO was similar; however, the more primitive KLS cells ( Figure 4C ) showed a trend toward reduction in Jag2 ECKO mice compared with Jag2 fl/fl mice.
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Endothelial jagged-2 sustains hematopoietic stem and progenitor reconstitution after myelosuppression.
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