HIV-1 gp120 and Modified Vaccinia Virus Ankara (MVA) gp140 Boost Immunogens Increase Immunogenicity of a DNA/MVA HIV-1 Vaccine.

Highly significant differences (raw P < 0.01) were found after the 3rd boost for C2.2 (MVA+MVAgp140 and MVA+gp120 > MVA only) and after the 2nd boost for C5.1 (MVA+MVAgp140 > MVA only and MVA+gp120) and C5.2 (MVA+MVAgp140 > MVA only) ( Fig. 3C and Table 2 ).

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The MVA-only group showed a trend for higher proportions of binding responses targeting KE, with 23.2% and 17.1% of total linear epitope binding intensities targeting KE at weeks 28 and 42, respectively, compared to 0.8% to 6.1% for other groups ( Fig. 3A ).

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