CRISPR/Cas9-derived models of ovarian high grade serous carcinoma targeting Brca1, Pten and Nf1, and correlation with platinum sensitivity.

Loss of p53 function produced a highly significant reduction in time to reach humane endpoints - median survival (Fig. 5D ; median 34.5 days vs 90 days; p < 0.0001).

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Mice bearing the triple-deleted Trp53 −/− ; Brca2 −/− ; Pten −/− tumours survived 99 days, which was significantly more than Trp53 −/− (p < 0.0001; Table 2 ) but less than Trp53 −/− ; Brca2 −/− , although this latter comparison did not reach statistical significance (p = 0.078).

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