Pak2 is essential for the function of Foxp3+ regulatory T cells through maintaining a suppressive Treg phenotype.

Sci Rep · 2017 · PMC5719048 · PMID 29213081

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did not reach statistical significanceno p-value reported

Although levels did not reach statistical significance, IFN-γ was appreciably increased in the serum of Foxp3 -Cre Pak2-deficient mice, further suggesting that, in addition to Th2 cells, Th1 cells may contribute to the observed inflammatory immunopathology.

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