Auditory closed-loop stimulation of EEG slow oscillations strengthens sleep and signs of its immune-supportive function.

An increase in aldosterone levels during the eighth hour and in prolactin levels during the third hour after stimulation onset approached significance ( p ≤ 0.075; Fig. 2c, d and Supplementary Fig. 3b, c ), with exploratory analyses revealing enhanced prolactin levels after stimulation at two of the 15-min samplings (150 min and 165 min post-stimulation onset, respectively, p ≤ 0.050).

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3c ) and failed to reach significance after clustering data of the frequent blood samplings into 1-h bins.

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