Merkel cell polyomavirus small T antigen induces genome instability by E3 ubiquitin ligase targeting.

Out of the 50 metaphase spreads that were analyzed for each condition, WT sT-expressing cells showed an increase in total number of chromosome breakages and gaps, a greater number of breakages within a single cell and an overall higher average number of breakages per cell ( Table 1 ) that did not reach statistical significance compared to empty control.

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