We found a trend toward higher levels of circulating IL‐6 in patients with OSA and NASH, but the differences between the groups did not reach statistical significance (Controls, 0.35 versus OSA/NASH 0.98 pg/mL, P = 0.33; OSA/NASH versus SS/no OSA, 0.77 pg/mL, P = 0.31) (Fig. 5 A).
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Intermittent hypoxia is a proinflammatory stimulus resulting in IL-6 expression and M1 macrophage polarization.
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