Paediatric European Network for Treatment of AIDS (PENTA) guidelines for treatment of paediatric HIV-1 infection 2015: optimizing health in preparation for adult life.

HIV Med · 2018 · PMC5724658 · PMID 25649230

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did not reach statistical significanceno p-value reported

There are no randomized comparisons of these strategies; however, evaluation of emergent resistance mutations in the SMART trial showed higher rates of follow‐up resistance mutations in patients undertaking a simultaneous or staggered stop compared with a replacement stop (although this did not reach statistical significance) 208 .

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