A case-control collapsing analysis identifies epilepsy genes implicated in trio sequencing studies focused on de novo mutations.

PLoS Genet · 2017 · PMC5724893 · PMID 29186148

Europe PMC DOI

hedged sentence

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closest p · 1.0× alpha

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boldest claim

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nominally significantp<0.05actually significant

In addition, six of the 10 most significantly associated genes are known EE genes, and the majority of the known EE genes (17 out of 25) originally implicated in trio sequencing are nominally significant (p<0.05), a proportion significantly higher than the expected (Fisher’s exact p = 2.33×10 −17 ).

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