Inhibition of aldehyde dehydrogenase 1 enhances the cytotoxic effect of retinaldehyde on A549 cancer cells.

Retinaldehyde combined with ALDH inhibition increases reactive oxygen species in A549 cells In initial experiments performed at a single time point of 2 h, a combination of retinaldehyde and DEAB increased ROS production in A549 cells to 152.5 ± 20.6% of that in controls, whereas the stimulatory effect of retinaldehyde alone did not reach statistical significance (Figure 4A ).

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