CXCR4 blockade decreases CD4+ T cell exhaustion and improves survival in a murine model of polymicrobial sepsis.

PLoS One · 2017 · PMC5726761 · PMID 29232699

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did not reach statistical significanceno p-value reported

Analysis of the effect of plerixafor administration on PD-1 expressing CD8 + T cells ( Fig 4B ) revealed a trend toward a decreased percentage and MFI of PD-1+ among CD8 + T cells as compared to septic control mice ( Fig 4E and 4F ) but these results did not reach statistical significance.

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