Extensive Homeostatic T Cell Phenotypic Variation within the Collaborative Cross.

In addition to this QTL, we also identified a highly significant QTL ( HI2 ) within the X chromosome at position 100–106 Mb driving the frequency of CXCR3+ Tregs ( Figure 5 A), CXCR3+ CD4+, and CD8+ T cells (data not shown).

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When we examined the founder effects, we found that PWK/PhJ again was a significant driver of this QTL for all three phenotypes ( Figure 5 B and data not shown), with a clear trend toward low levels of CXCR3 expression on all three subsets of T cells of CC-RIX lines when there were PWK/PhJ variants at position 105.5 Mb on the X chromosome ( Figures 5 C and 5D and data not shown).

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