Cardiovascular Risk Factors in Children and Adolescents with Subclinical Hypothyroidism.

BMI SDS was higher in children and adolescents with SCH though it failed to reach statistical significance ( P = 0.069).

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Bakker et al ., in a group of healthy euthyroid subjects, reported a strong, positive relationship between TSH and LDL in insulin-resistant subjects but not in insulin-sensitive subjects.[ 24 ] In the Busselton study, serum total cholesterol was significantly higher in subjects with SCH than in euthyroid subjects, but the difference was barely significant after adjustment for age and sex.[ 25 ] Moreover, LDL was significantly increased in subjects with mild SCH and TSH levels of at least 10 mIU/L.[ 25 ] In a study by Kvetny et al ., SCH was associated with a higher concentration of TGs and CRP.[ 26 ] The conflicting results of lipid pattern and SCH might reflect differences in the population studied (e.g., cause of SCH, duration of thyroid dysfunction, TSH levels), as well as differences in age, gender, and ethnicity of the subjects tested.

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