Barely Significant
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PCSK 9 gain-of-function mutations (R496W and D374Y) and clinical cardiovascular characteristics in a cohort of Turkish patients with familial hypercholesterolemia.

Anatol J Cardiol · 2017 · PMC5731522 · PMID 28777095

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These differences did not reach statistical significance probably due to the small number of patients with PCSK9 mutations.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.