Inhibiting DPP4 in a mouse model of HHT1 results in a shift towards regenerative macrophages and reduces fibrosis after myocardial infarction.

PLoS One · 2017 · PMC5734765 · PMID 29253907

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0.0900

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0.0900

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showed a trendP = 0.09so close (0.05 < p ≤ 0.1)

Analysis of cardiac function showed a trend towards reduced ejection fraction (EF) in the LysM-Cre- Eng fl/fl mice ( Fig 1D , WT 34.07±3.65% vs LysM-Cre- Eng fl/fl 22.73±4.30%, P = 0.09), suggesting an involvement of endoglin in macrophage function during cardiac repair.

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