By evaluating the concentrations of each agent (on a molar basis of MMAE) that inhibited cellular viability by 50% after 72 h (i.e., the IC 50 values), a clear trend emerged: the relative potency of free MMAE > NP(MMAE) > CNP(MMAE) for each cell line (Supplementary Table 3 ).
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Nanoparticle conjugates of a highly potent toxin enhance safety and circumvent platinum resistance in ovarian cancer.
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