in a study on gynecological ambulatory surgeries found that requirement for rescue analgesia was reduced in flupirtine group as compared to group ibuprofen but failed to reach statistical significance.[ 29 ] In our study, esmolol dose and the number of patients treated with it were significantly less in flupirtine-pretreated group while compared with placebo group.
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Evaluation of Preoperative Flupirtine in Ambulatory Functional Endoscopic Sinus Surgery: A Prospective, Double-Blind, Randomized Controlled Trial.
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