RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia.

In line with these findings, gene set enrichment analysis (GSEA) showed a highly significant enrichment of regions decorated with H3K27me3, either alone or in combination with H3K4me2/3, and of regions bound by PRC2 components including EED and SUZ12 (Supplementary Fig. 5d ).

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When considering only cases informative for outcome after HSCT and excluding patients with Noonan syndrome, CBL mutation or incomplete mutational analysis ( n = 92; Supplementary Table 3 ), OS still tended to be inferior in the HM group, but the comparison failed to reach statistical significance (Supplementary Fig. 3a ).

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