It should be noted that while all Group A and B compounds showed a consistent trend for increased permeation across the intestinal tissue of the knockout mice the data for two of the Group B compounds, GSK3 and salmeterol, failed to reach statistical significance ( P > 0.05) (Table III ).
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The Differential Absorption of a Series of P-Glycoprotein Substrates in Isolated Perfused Lungs from Mdr1a/1b Genetic Knockout Mice can be Attributed to Distinct Physico-Chemical Properties: an Insight into Predicting Transporter-Mediated, Pulmonary Specific Disposition.
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