Alterations in Mitochondrial Oxidative Stress and Mitophagy in Subjects with Prediabetes and Type 2 Diabetes Mellitus.

Regression Analysis to Determine the Association between HOMA-β and Mitophagy Markers In the control group, the variation in HOMA-β indices contributed by mitophagy-related genes ( PINK1, MFN2, NIX , and LC3-II ) was observed to be only 16.9%, which was statistically non-significant, whereas in subjects with prediabetes, variation in HOMA-β associated with these genes was 60.6%, which was highly significant ( p = 0.005).

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Furthermore, in subjects with prediabetes, there was a decreasing trend toward the aspect ratio and degree of mitochondrial branching complexity as measured by the form factor, though it did not reach statistical significance.

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