AIO LQ-0110: a randomized phase II trial comparing oral doxycycline versus local administration of erythromycin as preemptive treatment strategies of panitumumab-mediated skin toxicity in patients with metastatic colorectal cancer.

Oncotarget · 2017 · PMC5739620 · PMID 29285233

Europe PMC DOI

hedged sentences

0.0690

closest p · 1.4× alpha

0.0690

boldest claim

The sentences

a clear trendP =. 069so close (0.05 < p ≤ 0.1)

An obvious difference between both arms appeared on day 15 (day one of cycle 2) and this remained discernible thereafter indicating a clear trend towards superior efficacy of the standard arm using doxycycline ( P =. 069 ).

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a numerical trendno p-value reported

A numerical trend to a lower grade 3 toxicity with oral doxycycline can be discerned but without reaching statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.