NNT is a key regulator of adrenal redox homeostasis and steroidogenesis in male mice.

There was a modest reduction in gene expression levels of the antioxidants Prdx3 and Txnrd2 which did not reach statistical significance, however at the protein level they were significantly reduced in Nnt −/− mice vs Nnt +/+ and the levels remained significantly low in Nnt BAC when compared to Nnt +/+ ( Fig. 6C and D ).

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