Systems Pharmacology Dissection of Cholesterol Regulation Reveals Determinants of Large Pharmacodynamic Variability between Cell Lines.

Cell Syst · 2017 · PMC5747350 · PMID 29226804

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For example, knockdown of SREBF1 resulted in a significantly increased abundance of the SREBP2 target proteins FDFT1, HMGCS1, and IDI1 in Huh7 cells ( Table S1 ; Figures 3 E and 4 B), and showed a trend for increased expression of other cholesterol synthesis enzymes in HepG2, HEK293, and HeLa cells ( Table S1 ; Figures 3 E and 4 B).

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