Fn1 and Col1a1 started increasing in both groups already 1 day after UUO, but did not reach statistical significance ( S2B and S2C Fig ).
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Angiopoietin-1 deficiency increases renal capillary rarefaction and tubulointerstitial fibrosis in mice.
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Real time PCR showed that Tek was significantly downregulated 1 day after UUO in both WT and Angpt1KO to a similar degree, whereas Pecam1 showed a decreasing trend without reaching statistical significance ( S4A and S4B Fig ).