In the HOME study (Health Outcomes and Measures of the Environment), increased T 3 and T 4 levels were found associated to the maternal serum levels of two congeners of PBEs (28 and 47, with a median concentration of 1.0 and 19.1 ng/g lipid respectively), in the second trimester of pregnancy; a significant trend was found also between maternal levels of TT 4 and PBE-47 in the third trimester of pregnancy [ 20 ].
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Within the pesticides analysed, endrin concentration in placenta (geometrical mean of 2.53 ng/g placenta) was associated with increased TSH in the cord blood, and marginally significant association was found with other few pesticides analysed [ 42 ].