Sphingosine-1-Phosphate Receptor 1, Expressed in Myeloid Cells, Slows Diet-Induced Atherosclerosis and Protects against Macrophage Apoptosis in Ldlr KO Mice.

Although there was a slight trend towards higher average plaque size in Ldlr BM S1pr1 MKO versus Ldlr BM S1pr1 MWT mice fed the HF diet for 12 weeks (193,000 ± 21,000 μm 2 versus 173,000 ± 15,000 μm 2 , respectively), the data did not reach statistical significance.

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S1PR1 transcript levels in neutrophils from wild type or S1pr1 MWT mice appeared to be lower than in macrophages from corresponding mice and we saw a trend towards reduced S1PR1 transcripts in neutrophils from S1pr1 MKO compared to neutrophils from S1pr1 MWT mice, which did not reach statistical significance ( Figure 1 a).

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