Association between diacylglycerol kinase kappa variants and hypospadias susceptibility in a Han Chinese population.

The other seven SNPs, including the variant in CCNB3 , did not reach statistical significance with P < 0.05.

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6 , 7 , 8 However, in China, the prevalence of hypospadias has shown an increasing trend, particularly in well-developed areas. 9 , 10 Although the etiology of hypospadias is largely unknown, genetic factors have been demonstrated to play an important role in the development of hypospadias. 11 , 12 Hypospadias is a complex disease affected by both genetic and environmental factors.

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