Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis.

Nonetheless, neuronal tissues were consistently prioritised, and nominally significant regions, such as midbrain structures and spinal cord, have previously been implicated in restless legs syndrome. 51 At present, major concepts in the pathophysiology of restless legs syndrome address alterations in the dopaminergic neurotransmitter system and in brain iron metabolism, and are suppo

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