A genome-wide association study identifies only two ancestry specific variants associated with spontaneous preterm birth.

We analyzed 307 PTB cases and 2,826 controls from the Latino population from the Genes-environments and Admixture in Latino Americans babies (GALA II) study 67 and found that variant rs17591250 on chromosome 1 was modestly significant (OR = 0.7, P = 0.02775;, however, we observed a flip in the odds ratio (OR) for this population.

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We found rs17591250 was nominally significant in the EUR population (OR = 0.563, P = 0.04842), however we again observed a flip in the OR, which could be explained by the difference in allele frequencies in the different populations.

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