Protein methyltransferases and demethylases dictate CD8+ T-cell exclusion in squamous cell carcinoma of the head and neck.

Oncotarget · 2017 · PMC5762551 · PMID 29348866

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Furthermore, higher expression levels of three genes, SMYD2, SMYD3 and KDM3A, were associated or showed a trend for worse overall survival in HPV-negative SCCHN patients, though the chemokine signature or CD8 mRNA levels were not associated with overall survival.

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