Impaired epidermal Langerhans cell maturation in TGFβ-inducible early gene 1 (TIEG1) knockout mice.

However, after 60 hours of in vitro culture, the expression level of MHC-II, CD80 and CD86 in TIEG1-deficient LCs were considerably lower than their normal counterparts, although the difference in CD80 expression did not reach statistical significance (Figure 3D–3F ).

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