Evaluation of role of trace elements in oral submucous fibrosis patients: A study on Gujarati population.

J Oral Maxillofac Pathol · 2017 · PMC5763875 · PMID 29391727

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a definite trendno p-value reported

Furthermore, a definite trend was observed with gradual increase in serum copper level as the clinical stage and histological grade of OSMF increased which is in accordance with the study of Tadakamadla et al .[ 6 ] Thus, there could be a direct relation between serum copper and extent of fibrosis.[ 6 , 15 , 26 , 30 ] Copper is an essential cofactor for expression of enzyme lysyl oxidase.

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a significant trendno p-value reported

These events lead to cross-linking of collagen and elastin, making it less degradable.[ 6 , 15 , 24 , 26 , 27 ] A significant trend was observed with gradual decrease in serum iron level as the clinical stage and histological grade of OSMF increased.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.