The spectrum of cardiovascular effects of dobutamine - from healthy subjects to septic shock patients.

Rev Bras Ter Intensiva · 2017 · PMC5764562 · PMID 29340539

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showed a trendno p-value reported

( 3 ) In patients with severe heart failure, a meta-analysis also showed a trend towards worse outcomes with its use.

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a nonsignificant trendno p-value reported

On the other hand, a controlled crossover trial in patients with septic shock found detrimental effects of dobutamine on muscle and hepatic perfusion, a lack of improvement in peripheral perfusion, and a nonsignificant trend toward an increase in the proportion of perfused sublingual capillaries.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.