Calcium-phosphate complex increased during subchondral bone remodeling affects earlystage osteoarthritis.

Sci Rep · 2018 · PMC5765022 · PMID 29323204

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showed a trendno p-value reported

Although conflicting data have been reported, the NIH Osteoarthritis Initiative cohort study showed a trend for reduced knee joint space narrowing following bisphosphonate use after 4 years 39 .

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a decreasing trendno p-value reported

The ToF-SIMS analysis of Ca 2+ and PO 3 − levels in articular cartilage revealed an increase in Ca 2+ in the DMM surgery group, while PO 3 − levels showed a decreasing trend in the DMM group compared to the those in the sham group.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.