Pan-cancer screen for mutations in non-coding elements with conservation and cancer specificity reveals correlations with expression and survival.

NPJ Genom Med · 2018 · PMC5765157 · PMID 29354286

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0530

boldest claim

The sentences

highly significantp = 8.1 × 10 −28actually significant

In general a highly significant correlation between miR-122 expression levels and target gene perturbation was observed in HCC samples ( p = 8.1 × 10 −28 ).

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nominally significantp = 3.7 × 10 −2actually significant

The significant expression correlation was primarily driven by mutations at two known cancer drivers TP53 ( p = 2.3 × 10 −4 ) and GATA3 ( p = 2.1 × 10 −4 ), with MYC also nominally significant ( p = 3.7 × 10 −2 ).

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borderline significancep = 0.053so close (0.05 < p ≤ 0.1)

In combination, the expression correlation of the full set of TFBS mutations showed borderline significance ( p = 0.053; Fig. 5g ), with a limited set of genes that deviate from the expected p -values.

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near significanceno p-value reported

58 For non-coding elements, enhancer nearby TERT is ranked first in the whole-genome data set with near significance ( q = 0.32; Supplementary Table 15 ).

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