The intriguing evolution of effect sizes in biomedical research over time: smaller but more often statistically significant.

ESs were more likely to be significant in regions where they were the highest (Fig. 1 B, Additional Table S5 ).

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In contrast, while we also measured decreasing ESs, our findings indicated a clear trend toward a growing proportion of statistically significant results over time.

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There was no evidence of an increasing trend in abstracts of reviews ( Additional Fig.

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