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Phase I Clinical Study of ZYAN1, A Novel Prolyl-Hydroxylase (PHD) Inhibitor to Evaluate the Safety, Tolerability, and Pharmacokinetics Following Oral Administration in Healthy Volunteers.

Clin Pharmacokinet · 2018 · PMC5766731 · PMID 28508936

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showed a trendno p-value reported
The mean serum EPO concentrations showed a trend of dose response.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.