Novel analgesic effects of melanin-concentrating hormone on persistent neuropathic and inflammatory pain in mice.

After reaching peak levels of pain, the withdrawal frequency was still higher in pMCH −/− mice (111% and 109% of pMCH +/+ mice on Days 4 and 7, respectively), but these differences did not reach statistical significance (each p > 0.05; Fig. 2E ).

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