Neither the genotype nor the intracerebral injection procedure had an effect on the escape latency during the learning phase (Fig 6 A), although seeded 5xFAD mice showed a trend that did not reach significance toward impaired reversal learning (Fig 6 C), seeded 5xFAD mice spent significantly less time in the target quadrant when compared to non‐injected WT or 5xFAD mice or mice that had been injected with brain homogenate (Fig 6 B and D).
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Seed-induced Aβ deposition is modulated by microglia under environmental enrichment in a mouse model of Alzheimer's disease.
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