Barely Significant
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Silymarin prevents acetaminophen-induced hepatotoxicity in mice.

PLoS One · 2018 · PMC5771617 · PMID 29342206

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a decreasing trendno p-value reported
Along with the prolonged time from APAP administration, HO-1 expression exhibited a decreasing trend in all groups.

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SLM-pretreated groups exhibited a tendency for less GSH depletion but this did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.