Correlations between mitochondrial DNA haplogroup D5 and chronic hepatitis B virus infection in Yunnan, China.

With HCs and SRs pooled together, the association of D5 and chronic HBV infection was highly significant ( P = 0.008, OR = 2.81, 95% CI = 1.32–6.00) (Table 3 ).

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We also found that CHBs belonging to haplogroup D5 showed a trend towards having a very high VL and a lower frequency of VL <100 IU/mL (Fig. 3 ), which was considered as the cut-off for clinical HBV-DNA negativity.

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