Chronic dietary creatine enhances hippocampal-dependent spatial memory, bioenergetics, and levels of plasticity-related proteins associated with NF-κB.

χ 2 analysis comparing the frequency of strategy use between groups collapsing the first three training days, by which time peak spatial strategy use was achieved in Cr-fed mice, fell just short of significance ( P = 0.057).

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In the present study, although hippocampal Cr levels were 8.7% higher in absolute terms in supplemented mice, this did not reach statistical significance.

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