Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures.

Nat Commun · 2018 · PMC5773483 · PMID 29348617

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showed a trendno p-value reported

While Atg5 KO alone showed a trend for increased secretion of the EV markers analyzed, VPS34IN1 treatment caused a much more dramatic effect in EV-associated APP-CTFs and a comparable fold increase in both naive and Atg5 KO cells (Supplementary Fig. 7d ).

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