Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40 138 bleeding patients.

Lancet · 2018 · PMC5773762 · PMID 29126600

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a clear trendno p-value reported

With the exception of the first hour, we found a clear trend of decreasing effectiveness with increasing treatment delay.

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