5-aminosalicylic acid improves lipid profile in mice fed a high-fat cholesterol diet through its dual effects on intestinal PPARγ and PPARα.

However, mice receiving 5-ASA showed a trend towards lower plasma triglycerides (0.91±0.12 vs. 0.59±0.10, P = 0.052, Fig 1E ), whereas no effect was seen on the plasma levels of free ( Fig 1F ) and total cholesterol ( Fig 1G ). 5-ASA treatment improves plasma lipid levels in HFC-fed mice To assess whether 5-ASA may improve plasma lipid levels in the setting of diet-induced obesity (DIO), we challenged C57BL/6J mice with either a HFC diet or HFC incorporated with 5-ASA for 12 weeks.

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